<!DOCTYPE DOCUMENT SYSTEM "icon.dtd" []>

<DOCUMENT author="perl program" datec=020199 title="leaflet" book="ABPI" edition="1996-97" section="company">
<PB n=1>
<CB n=1>
<DIV type=0>

<HEAD weight="bold" >
Menorest Transdermal Therapeutic System (Each MENOREST patch contains 17&szlig;-Oestradiol)
</HEAD>


<BLOCK>
Please read this leaflet carefully before you start to use your patches. This leaflet is a summary of the important information about Menorest. If you have any questions, or are not sure about anything to do with your treatment, ask your doctor or pharmacist for more information. Keep this leaflet in a safe place. You may want to refer to it again.
</BLOCK>

<DIV type=1>

<HEAD weight="bold" >
What are Menorest patches?
</HEAD>


<BLOCK>
The active ingredient in the patch is 17&szlig;-Oestradiol. Three strengths of Menorest patches are available:
</BLOCK>


<BLOCK>

<EMPH weight="bold">
Menorest 37.5: 
</EMPH>
17&szlig;-Oestradiol content 3.29 mg. Delivering 37.5 micrograms (µg) 17&szlig;-Oestradiol per day.
</BLOCK>


<BLOCK>

<EMPH weight="bold">
Menorest 50:
</EMPH>
 17&szlig;-Oestradiol content 4.33 mg. Delivering 50 micrograms (µg) 17&szlig;-Oestradiol per day.
</BLOCK>


<BLOCK>

<EMPH weight="bold">
Menorest 75:
</EMPH>
 17&szlig;-Oestradiol content 6.57 mg. Delivering 75 micrograms (µg) 17&szlig;-Oestradiol per day.
</BLOCK>


<BLOCK>
You can tell which patch your doctor has prescribed by the packaging and the pharmacist's label.
</BLOCK>


<BLOCK>
Each patch also contains the following inactive ingredients: polyisobutylene, ethylene vinyl acetate copolymer, butylene glycol, oleic acid, lecithin, propylene glycol, bentonite, mineral oil, dipropylene glycol, Duro-Tak adhesive and styrene-butadiene rubber.
</BLOCK>


<BLOCK>
Menorest is available in packs of 8 patches.
</BLOCK>


<BLOCK>
17&szlig;-Oestradiol is an oestrogen hormone which occurs naturally in humans. It is one of the important female hormones.
</BLOCK>


</DIV>
<DIV type=1>

<HEAD weight="bold" >
Who makes Menorest patches?
</HEAD>


<BLOCK>
The Product Licence holder is May &amp; Baker Ltd, Eastbourne, East Sussex, a member of the Rh&ocirc;ne-Poulenc Rorer group of companies. Menorest patches are manufactured by Rh&ocirc;ne-Poulenc Rorer Pharmaceuticals Ltd, Nenagh, Co Tipperary, Republic of Ireland.
</BLOCK>


</DIV>
<DIV type=1>

<HEAD weight="bold" >
Why have you been prescribed Menorest patches?
</HEAD>


<BLOCK>
Menorest patches are used in hormone replacement therapy (HRT).
</BLOCK>


<BLOCK>

<EMPH slant = "italic">
Menorest is NOT to be used as a contraceptive. If you need advice about family planning talk to your doctor.
</EMPH>

</BLOCK>


</DIV>
<DIV type=1>

<HEAD weight="bold" >
Before applying your Menorest patches for the first time
</HEAD>


<BLOCK>
If the answer is YES to any of the following questions you should discuss the matter with your doctor o; pharmacist BEFORE starting to use Menorest.
</BLOCK>


<BLOCK>
This is a list of possible reasons why it may not be appropriate for you to use Menorest.
</BLOCK>


<LIST type="bulleted">

<ITEM>

<BLOCK>
Are you sensitive or allergic to any oestrogens?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Are you sensitive or allergic to any of the inactive ingredients?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Are you pregnant, planning a pregnancy or think you may be pregnant.
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Are you breast feeding?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have, or have you ever had, cancer of the breast or uterus?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Have you experienced any unusual vaginal bleeding recently?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have any liver or kidney problems?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have, or have you had, any serious hearing difficulties?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have, or have you recently experienced any pain or tenderness around a vein, particularly in your legs?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have a high cholesterol or triglyceride level in your blood?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you suffer from asthma, epilepsy or migraine?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have any heart problems?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have porphyria?
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Do you have hypophysis tumours (tumour in a certain area of the brain)?
</BLOCK>

</ITEM>

</LIST>



<BLOCK>
Before you use Menorest you must be examined by <CB n=2> your doctor. Your breasts should be examined on a regular basis especially if there is a family history of breast cancer. You should also see your doctor on a yearly basis for a complete physical examination.
</BLOCK>

<DIV type=2>

<HEAD slant="italic" >
You should NOT use Menorest if you are:
</HEAD>


</DIV>
<DIV type=2>

<HEAD slant="italic" >
a male a pre-menopausal female or a child
</HEAD>


</DIV>

</DIV>
<DIV type=1>

<HEAD weight="bold" >
Are you taking any other medicines?
</HEAD>


<BLOCK>

<EMPH slant = "italic">
Some medicines may change the way Menorest
</EMPH>
 
<EMPH slant = "italic">
works. It you are taking any of the following, tell your 
<EMPH slant = "italic">
doctor BEFORE you use Menorest
</EMPH>

</EMPH>

</BLOCK>


<LIST type="bulleted">

<ITEM>

<BLOCK>
Any treatment for epilepsy, particularly phenytoin or carbamazepine
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Barbiturates (for severe sleeping difficulties)
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Meprobamate (for anxiety)
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Phenylbutazone (for ankylosing spondylitis)
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Rifampicin (an antibiotic)
</BLOCK>

</ITEM>

</LIST>



</DIV>
<DIV type=1>

<HEAD weight="bold" >
How often should you apply a Menorest patch?
</HEAD>


<BLOCK>
Apply one patch twice a week.
</BLOCK>


<BLOCK>
Leave a patch on for 3 or 4 days.
</BLOCK>


<BLOCK>
Always change your patch on the same days of the week (You may find it useful to stick the "day of the week" sticker onto a suitable surface as a reminder when to apply your next patch).
</BLOCK>


<BLOCK>
After this time remove the old patch and dispose of it carefully.
</BLOCK>


<BLOCK>
Apply a new patch to a 
<EMPH slant = "italic">
different area of skin.
</EMPH>

</BLOCK>


<BLOCK>

<EMPH weight="bold">
It is important to use your patches as directed by
</EMPH>
 
<EMPH weight="bold">
your doctor. The pharmacist's label should tell you when and how often to apply them. If it does not, or you are not sure how to use the patches, ask you doctor or pharmacist.
</EMPH>

</BLOCK>


<BLOCK>
Your doctor should monitor your treatment and may change the strength of the MENOREST patch you use.
</BLOCK>


<BLOCK>

<EMPH slant = "italic">
If you have an intact uterus - i.e. you have not had a hysterectomy- your doctor will also have prescribed another female hormone called progestogen. You should take the progestogen medicine for at least 72 days each month, normally during the last two weeks of the month.
</EMPH>

</BLOCK>


</DIV>
<DIV type=1>

<HEAD weight="bold" >
Where should you stick the patches?
</HEAD>

<DIV type=2>

<HEAD>
What MUST you do
</HEAD>


<LIST type="bulleted">

<ITEM>

<BLOCK>
Stick the Menorest patches onto the skin anywhere on the lower back, stomach, buttocks or the tops of your legs
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Apply the patch to an area of skin which will be covered by clothing. The patch should not be exposed to direct sunlight
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Wear only one Menorest patch at a time
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Change where you put the patch each time in order to give your skin a rest But DO NOT apply the patch
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>

<EMPH slant = "italic">
To your breasts or near to your breasts
</EMPH>

</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Where your skin is oily, scratched or sore, as this may change the absorption of the medicine
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Where it will be rubbed by tight clothing - for example at the waist - as the patch may come off
</BLOCK>

</ITEM>


<ITEM>

<BLOCK>
Where you have used creams, lotions or powders they may prevent the patch from sticking onto the skin
</BLOCK>

</ITEM>

</LIST>



</DIV>

</DIV>
<DIV type=1>

<HEAD weight="bold" >
How to put the patch on?
</HEAD>


<LIST type="ordered">

<ITEM>

<BLOCK>
Tear open the pouch along the 2 edges using your fingers.
</BLOCK>

</ITEM>

</LIST>



<BLOCK>
Do not use scissors as this may damage the patch Inside.
</BLOCK>

<FIGURE></FIGURE>
<PB n=2>
<FIGURE></FIGURE>
</DIV>

</DIV>

</DOCUMENT>
