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<DOCUMENT author="perl program" datec=020199 title="leaflet" book="ABPI" edition="1996-97" section="company">
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Ukidan 
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Please read this leaflet carefully before your treatment is started. This leaflet provides a summary of the information available on your medicine. If you have any questions or are not sure about anything, ask your doctor.
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What You Should Know About Ukidan (Urokinase)
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The name of your medicine is 
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Ukidan
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. It is available as a white powder in three different strengths containing 5000, 25000 or 100000 IU of the active ingredient which is called urokinase. It will be made up (dissolved) in water or saline before it is given to you. All strengths are available in single vials.
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What's In Your Medicine?
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In addition to Urokinase, Ukidan also contains Mannitol, Disodium Edetate and Disodium Hydrogen Phosphate.
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The Product Licence Holder:
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Serono Laboratories (UK) Ltd 99 Bridge Road East Welwyn Garden City Herts AL7 1BG
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The Product Is Manufactured By:
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Industria Farmaceutica Serono S.p.A
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Via Casilina, 125 00176 Rome Italy
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Why Ukidan?
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Your doctor has prescribed this medicine for you because you have a condition which is causing unwanted blood clots to form. 
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Ukidan
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 contains Urokinase, a substance which occurs naturally in the body. It is used to dissolve blood clots. There are several conditions that the medicine Is used for, which are described briefly below:
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To treat thrombosis (blood clot) in a vein or artery
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<ITEM>

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To treat hyphaema (bleeding into the chamber of the eye)
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To unblock the tubes which are used to administer drugs or dialysis if they become blocked by a clot.
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Your doctor can explain your treatment to you.
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Who Should Not Be Given Ukidan?
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Usually it is alright for you to be given 
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Ukidan
</EMPH>
 if your doctor has prescribed it. However, if you think any of the following situations apply to you then speak to your doctor.
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You are pregnant or think you could be pregnant.
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You have had a baby in the last few days.
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You have had an operation or any surgery within the last 3 days.
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You have had any problems with your liver or kidneys.
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You have very high blood pressure.
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You have a peptic ulcer.
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You have had to be resuscitated in hospital and have therefore had treatment which involved the use of tubes or needles (injections). Your doctor will be able to discuss this with you.
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How Will Ukidan Be Given To You?
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<BLOCK>
The medicine will be given to you in hospital. As 
<EMPH weight="bold">
Ukidan
</EMPH>
 is used to treat several different conditions it can be given in different ways. However it is usually given by injection or by infusion through tubes into a vein. The dosage varies depending on what condition you are being treated for and on your weight. The treatment is usually short lasting only a few hours although some conditions involve a series of injections over 3 days. Your doctor or nurse will be able to explain how 
<EMPH weight="bold">
Ukidan
</EMPH>
 is being given to you.
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Can Ukidan Cause Side-Effects?
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Any medicine can cause side-effects. However most people who are given Ukidan do not have any problems.
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If however you are receiving 
<EMPH weight="bold">
Ukidan
</EMPH>
 to clear a dialysis shunt tube you may get a warm feeling some pain or a dull ache in the leg or arm itself. The pain should not East long.
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It is also possible that you may suffer from bleeding. This may only be slight but if you notice any bleeding then call a doctor or nurse. You may have a temperature for a short time. Occasionally some blood may appear in your urine.
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If you notice these or any other unwanted effects not mentioned above then please tell your doctor or nurse.
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How is Ukidan stored?
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<EMPH uline="plain">
Ukidan
</EMPH>

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Date of preparation: January 1995
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This is only a summary of the information that is available on 
<EMPH weight="bold">
Ukidan
</EMPH>
. If you have any questions after reading this leaflet please ask your doctor who will have additional information.
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Code:N0220200 UK
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